ea0025p118 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011
Hussain Ahkeb
, Hardy Rowan
, Patel Pushpa
, Ahassan Mohammad
, Filer Andrew
, Stewart Paul
, Cooper Mark
Rheumatoid arthritis (RA) is associated with a loss of lean mass and a corresponding increase in fat mass. How fat accumulation in RA is linked to synovial inflammation is unknown. Wnts comprise a family of secreted glycoproteins that are crucial in regulating adipocyte proliferation, apoptosis and differentiation. Recently we demonstrated that endogenously generated glucocorticoids (GCs) alter the pattern of wnt secretion by synovial fibroblasts (SFs), favouring production of...